| Autor: |
John B. Bremner, Paul A. Keller, Stephen G. Pyne, Mark J. Robertson, K. Sakthivel, Kittiya Somphol, Dean Baylis, Jonathan A. Coates, John Deadman, Dharshini Jeevarajah, David I. Rhodes |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1265-1270 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.8.142 |
| Popis: |
The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2–4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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