| Autor: |
Jing Liu, Ning Li, Wei Li, Qi Zhang, Qin Hui, Xiuxiu Lu, Yuanmei Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMJ Paediatrics Open, Vol 8, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2399-9772 |
| DOI: |
10.1136/bmjpo-2023-002329 |
| Popis: |
Background and objectives This study aimed to identify predictors of sepsis-associated in-hospital mortality from readily available laboratory biomarkers at onset of illness that include haematological, coagulation, liver and kidney function, blood lipid, cardiac enzymes and arterial blood gas.Methods Children with sepsis were enrolled consecutively in a prospective observational study involving paediatric intensive care units (PICUs) of two hospitals in Beijing, between November 2016 and January 2020. The data on demographics, laboratory examinations during the first 24 hours after PICU admission, complications and outcomes were collected. We screened baseline laboratory indicators using the Least Absolute Shrinkage and Selection Operator (LASSO) analysis, then we constructed a mortality risk model using Cox proportional hazards regression analysis. The ability of risk factors to predict in-hospital mortality was evaluated by receiver operating characteristic (ROC) curves.Results A total of 266 subjects were enrolled including 44 (16.5%) deaths and 222 (83.5%) survivors. Those who died showed a shorter length of hospitalisation, and a higher proportion of mechanical ventilation, complications and organ failure (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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