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Gitishree Das,1,2 Han-Seung Shin,3 Jayanta Kumar Patra1,2 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea; 2Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea; 3Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, Republic of KoreaCorrespondence: Jayanta Kumar Patra Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea Tel +82-31-961-5625 Email jkpatra.cet@gmail.comPurpose: Due to the biomedical applications universally, the Ag nanoparticles are one of the most commonly investigated nanoparticles (NPs). Curly kale (BroL) leaves contain numerous beneficial nutrients and phytochemicals. The aim of the current study is the fabrication of the Ag nanoparticles using the extracts of curly kale and to investigate their biological potentials.Methods: The characterization of the generated BroLAgNPs was done through UV-Vis spectro study, Fourier-transform infrared spectro study, scanning electron microscope analysis, energy-dispersive X-ray study, distribution of size and zeta potential investigation, and X-ray powder diffraction study, and their biological effects were evaluated by antidiabetic, antioxidant, antibacterial and cytotoxicity effect.Results: BroL-Ag nanoparticle displayed surface plasmon resonance at 432 nm. The Zeta potential of BroL (− 26.6) AgNPs displayed a highly negative charge. In antidiabetic assay, BroL-AgNPs was highly effective with IC50 value 2.29 μg/mL at 1.0 μg/mL concentration. In cytotoxicity assay, BroL-AgNPs displayed strong activity at 10.0 μg/mL concentration. It showed inhibitory action against three food-borne pathogenic bacteria (9.29– 11.44 mm inhibition zone) and displayed moderate antioxidant potential.Conclusion: This study as a whole report an eco-friendly green synthesis of AgNPs using leafy vegetable aqueous extract and its multi-biological effects which could serve as a promising candidate in pharmacological and related industries.Keywords: antidiabetic, antioxidant, antibacterial, cytotoxicity, curly kale, silver nanoparticle |
