Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Autor: Tran Dinh Thang, Ping-Chung Kuo, Tsong-Long Hwang, Mei-Lin Yang, Nguyen Thi Bich Ngoc, Tran Thi Ngoc Han, Chi-Wen Lin, Tian-Shung Wu
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Molecules, Vol 18, Iss 11, Pp 14285-14292 (2013)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules181114285
Popis: The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
Databáze: Directory of Open Access Journals