Anti-craving Property of Chlorpromazine in Pentazocine addiction among sickle cell disease patients: A Case Series
| Autor: | JOSHUA FALADE, Patrick Olarewaju Osho, Akindele Amos Ajayi, Ayodeji Oluwaseun Ogungbemi, Recheal Folashade Dare, Akinwumi Ayodele Akinnuoye, Sunday Sajo |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Babcock University Medical Journal, Vol 6, Iss 2 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2465-6666 2756-4657 |
| DOI: | 10.38029/babcockuniv.med.j..v6i2.182 |
| Popis: | Background: Opioids are useful in the management of vaso-occlusive crisis among Sickle Cell Disease patients; however, there is a need to search for drugs that can ameliorate the withdrawal symptoms without causing further dependence. Case presentations: Three patients living with Sickle cell disease abusing Pentazocine were managed with Tab Chlorpromazine 100mg twice daily for three weeks and had a significant reduction in the level of craving and also experienced improved sleep. Chlorpromazine demonstrates a high affinity for dopamine (DA) receptors and acts as a receptor antagonist by inhibiting adenylate cyclase activity. Conclusion: Chlorpromazine was found to be useful in the management of cravings associated with Pentazocine addiction. |
| Databáze: | Directory of Open Access Journals |
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