| Autor: |
Ömer Çelik, Ahmet Anıl Şahin, Serdar Sarıkaya, Begüm Uygur |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Anatolian Journal of Cardiology, Vol 24, Iss 5, Pp 303-308 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2149-2263 |
| DOI: |
10.14744/AnatolJCardiol.2020.54937 |
| Popis: |
Objective: A strong correlation exists between myocardial fibrosis and heart failure (HF). Myocardial fibrosis can be detected by cardiac magnetic resonance (CMR), which is a crucial noninvasive imaging method with high specificity and sensitivity. Matrix metalloproteinases (MMPs) are primary proteases responsible for the degradation of extracellular matrix (ECM) components, and they play a vital role in maintaining the balance between anabolism and catabolism of ECM. This study aims to investigate the correlation between cardiac fibrosis detected on CMR and serum MMP-9 levels in patients with HF. Methods: We enrolled 53 patients (age: ≥18 years) with left ventricular ejection fraction (LVEF) ≤40%, who received CMR because of various indications. All patients were divided into two groups-with cardiac fibrosis (n=32) and without cardiac fibrosis (n=21)-detected by CMR with late-Gadolinium. Both groups were then compared according to MMP-9 levels. Results: MMP-9 levels were significantly higher in patients with cardiac fibrosis than those without fibrosis (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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