| Autor: |
Alejandro Rodríguez-Molinero, Carlos Pérez-López, César Gálvez-Barrón, Antonio Miñarro, Oscar Macho, Gabriela F. López, Maria Teresa Robles, Maria Dolores Dapena, Sergi Martínez, Ezequiel Rodríguez, Isabel Collado Pérez, Anna Alberti Casas, Jose L. Avalos Garcia, Manel Borrego Ruiz, Gemma Añaños Carrasco, Pedro L. Campo Pisa, Ana M. Capielo Fornerino, Antonio Chamero Pastilla, Andreu Fenollosa Artés, Clara Gris Ambros, Lourdes Hernandez Martinez, Antonio Hidalgo García, Mireia Martín Puig, Núria Milà Ràfols, José C. Molina Hinojosa, Ernesto E. Monaco, Laura Peramiquel Fonollosa, Italo G. Pisani Zambrano, Juan P. Rives, Enric Sabria Bach, Yris M. Sanchez Rodriguez, Maria del Mar Segura Martin, Gemma Tremosa Llurba, Ester Ventosa Gili, Florencia I. Venturini Cabanellas, Natàlia Vidal Meler |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
One Health, Vol 12, Iss , Pp 100214- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2352-7714 |
| DOI: |
10.1016/j.onehlt.2021.100214 |
| Popis: |
Background: Tocilizumab has been proposed as a treatment for the new disease COVID-19, however, there is not enough scientific evidence to support this treatment. The objective of this study is to analyze whether the use of tocilizumab is associated with respiratory improvement and a shorter time to discharge in patients with COVID-19 and lung involvement. Methods: Observational study on a cohort of 418 patients, admitted to three county hospitals in Catalonia (Spain). Patients admitted consecutively were included and followed until discharge or up to 30 days of admission. A sub-cohort of patients treated with tocilizumab and a sub-cohort of control patients were identified, matched by a large number of risk factors and clinical variables. Sub-cohorts were also matched by the number of other treatments for COVID-19 that patients received. Increment in SAFI (inspired oxygen fraction / saturation) 48 h after the start of treatment, and time to discharge, were the primary outcomes. Mortality, which was a secondary outcome, was analyzed in the total cohort, by using logistic regression models, adjusted by confounders. Results: There were 96 patients treated with tocilizumab. Of them, 22 patients could be matched with an equivalent number of control patients. The increment in SAFI from baseline to 48 h of treatment, was not significantly different between groups (tocilizumab: −0.04; control: 0.09; p = 0.636). Also, no difference in time to discharge was found between the two sub-cohorts (logrank test: p = 0.472). The logistic regression models, did not show an effect of tocilizumab on mortality (OR 0.99; p = 0.990). Conclusions: We did not find a clinical benefit associated with the use tocilizumab, in terms of respiratory function at 48 h of treatment, or time to discharge. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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