Efficacy of a Combination of b-Tricalcium Phosphate with Hyaluronic Acid in the Management of Intrabony Periodontal Defects: A Prospective Clinical Study

Autor: Kavitha Selvaprakash, Lakshmi Ramachandran, Harinath Parthasarathy, ANUPAMA Tadepalli, Deepa Ponnaiyan, Janani Karthikeyan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical and Diagnostic Research, Vol 15, Iss 12, Pp 34-38 (2021)
Druh dokumentu: article
ISSN: 2249-782X
0973-709X
DOI: 10.7860/JCDR/2021/51879.15791
Popis: Introduction: Numerous bioactive grafts have been studied for periodontal defect regeneration of which, b-Tricalcium Phospate (β-TCP) is a very promising bone graft. Hyaluronic Acid (HA), an essential component of periodontal ligament matrix plays a pivotal role in tissue growth, repair and remodeling. Aim: To evaluate the efficacy of 0.8% HA as an adjunct to β-TCP in the treatment of isolated human intrabony defects. Materials and Methods: This prospective clinical study was conducted at the Department of Periodontics, SRM Dental College, Chennai, Tamil Nadu, India, from January 2017 and December 2017 (followed-up to June 2018). The study included 30 intrabony defects from 16 chronic periodontitis patients, 15 of each were randomly assigned into either test/control groups and were reviewed till six months. After phase I therapy regenerative osseous surgery was performed at all the sites. Control sites received β-TCP bone graft alone and test group received β-TCP with 0.8% HA. Postsurgical clinical evaluation of Probing Pocket depth (PPD) and Clinical Attachment level (CAL) was done at three and six months, radiographs were repeated at six months to assess the bone fill. Statistical analysis using Statistical Package for the Social Sciences (SPSS) version 22.0 was done, Mann-Whitney U test and Wilcoxon-Signed Rank test were used to compare the intergroup and intragroup values respectively. Results: The mean age of the control and test groups were 45.7 and 48.5 years respectively. The PPD was reduced, CAL and bone fill were increased in both groups from baseline, indicating clinical effectiveness. From baseline to six months, the PPD reduction and gain in CAL in the test and control groups were 3.27±0.18 mm, 3.20±0.18 mm and 3.07±0.03 mm, 3.07±0.08 mm, respectively, which was statistically significant (p-value 0.05) in both clinical and radiographic parameters. Conclusion: Hyaluronic acid as an adjunct to β-TCP demonstrated only comparable outcomes despite obtaining substantial bone fill and attachment gain.
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