| Autor: |
Neda Ansari, Vasudevan Ramachandran, Nur Afiqah Mohamad, Elnaz Salim, Patimah Ismail, Mohamad Hazmi, Liyana Najwa Inchee Mat |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Global Medical Genetics, Vol 10, Iss 01, Pp 012-018 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2699-9404 |
| DOI: |
10.1055/s-0042-1760384 |
| Popis: |
Background Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder, and the underlying causes remain unknown and have not been fully elucidated. Several candidate genes have been associated with T2DM in various populations with conflicting results. The variations found in glucokinase (GCK), glucokinase regulatory protein (GCKR), and glucose-6-phosphatase 2 (G6PC2) genes were not well studied, particularly among Asians. Aims The main objective of this study was to determine the candidate genetic polymorphisms of GCK (rs1799884), GCKR (rs780094), and G6PC2 (rs560887) genes in T2DM among Malay ethnics. Methods In this candidate gene association study, a total of 180 T2DM subjects and 180 control subjects were recruited to determine the genotypes using polymerase chain reaction-restriction fragment length polymorphism and Taqman probe assay methods. Genotype and allele frequencies in case and control samples were compared using the chi-squared test to determine a significant difference. Results The body mass index, fasting blood glucose, hemoglobin A1c, systolic and diastolic blood pressure, and total cholesterol were significantly different (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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