| Autor: |
Vladimir Y Bogdanov, Vladimir N Khirmanov |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
EFORT Open Reviews, Vol 4, Iss 1, Pp R35-R43 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2058-5241 |
| DOI: |
10.1530/VB-22-0004 |
| Popis: |
As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of ‘long COVID’ remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of SARS-CoV-2’s impact on endothelial cells and platelets likely play a significant role in the development of chronic symptomatology associated with COVID-19. In this brief overview, we discuss the recent findings pertaining to the detection of SARS-CoV-2 virions in vascular cell subtypes, the contribution of the coagulation system to the development of ‘long COVID’, and the potential role of stem/progenitor cells in the viral and thrombotic dissemination in this disorder. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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