Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report

Autor:	Sangeeta Mutnuri, Hania Kassem, John Badalamenti, You-Wen Qian, Christopher Marquez, Marjan Afrouzian
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Case Reports in Nephrology, Vol 2019 (2019)
Druh dokumentu:	article
ISSN:	2090-6641 2090-665X
DOI:	10.1155/2019/7940291
Popis:	We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous.
Databáze:	Directory of Open Access Journals
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