Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines

Autor:	Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Hassan Allouchi, Mohamed Abarbri, Fakher Chabchoub
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	multicomponent reaction one-pot reaction triazolopyrimidine breast cancer antitumoral Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 9, p 3917 (2023)
Druh dokumentu:	article
ISSN:	28093917 1420-3049
DOI:	10.3390/molecules28093917
Popis:	A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1H-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed by IR, 1H-NMR, 13C-NMR, HRMS and X-ray analyses. The biological activity of these compounds as antitumor agents was evaluated. Their antitumor activities against cancer cell lines (MDA-MB-231 and MCF-7) were tested by the MTT in vitro method. Among them, compounds 4c and 4j displayed the best antitumor activity with IC50 values of 17.83 μM and 19.73 μM against MDA-MB-231 and MCF-7 cell lines, respectively, compared to the Cisplatin reference.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b697ac12475a4749a87b29d4cf13a855 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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