Production of Anti-dementia Acetylcholinesterase Inhibitor from Pleurotus ostreatus (Heuktari) and Inhibitory Effect on PC12 Neuron Apoptosis
| Autor: | Sang-Min Han, Ji-Yoon Kim, Jong-Soo Lee |
|---|---|
| Jazyk: | English<br />Korean |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | 한국균학회지, Vol 47, Iss 4, Pp 337-346 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0253-651X 2383-5249 |
| DOI: | 10.4489/KJM.20190039 |
| Popis: | To develop a new antidementia acetycholinesterase (AChE) inhibitor from edible mushrooms, the inhibitory effects on AChE of water and ethanol extracts from various edible mushrooms were measured. Among the tested compounds, 70% ethanol extracts from Tremella fuciformis showed the highest AChE inhibitory activity, at 25.3% (ic50: 9.9 mg). Water extracts from the fruiting body of Pleurotus ostreatus (Heuktari) showed AChE inhibitory activity of 20.2% (ic50: 12.4 mg). However, the yield (40.8%) from Pleurotus ostreatus (Heuktari) was higher than that from Tremella fuciformis (5.0%). Therefore, we selected Pleurotus ostreatus (Heuktari) as the most promising candidate for a mushroom containing anti-dementia AChE inhibitors. TheAChE inhibitor from Pleurotus ostreatus (Heuktari) was optimally extracted when its fruiting body was treated with water for 6 h at 30℃. The anti-dementia effects of the partially purified AChE inhibitor from Pleurotus ostreatus (Heuktari) were observed in PC12 nerve cells. |
| Databáze: | Directory of Open Access Journals |
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