Lifespan trajectory of affect in Cornelia de Lange syndrome: towards a neurobiological hypothesis
Autor: | Laura Groves, Joanna Moss, Hayley Crawford, Lisa Nelson, Chris Stinton, Gursharan Singla, Chris Oliver |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-9 (2019) |
Druh dokumentu: | article |
ISSN: | 1866-1947 1866-1955 |
DOI: | 10.1186/s11689-019-9269-x |
Popis: | Abstract Background Depressive symptomology and low affect are comparatively common in individuals with genetic disorders such as Cornelia de Lange syndrome. However, lifespan trajectories and associated person characteristics have not been examined. In this study, the trajectories for affect and associated behavioural characteristics were investigated in individuals with Cornelia de Lange syndrome with individuals with fragile X syndrome (FXS) comparable for chronological age and total number of behavioural indicators of ASD included for the purpose of contrast. Methods A 7-year longitudinal study of affect (mood, interest and pleasure) was conducted in individuals with CdLS (n = 44) and FXS (n = 95). The trajectories of low affect were explored, as well as associations between Time 1 behavioural characteristics and affect at Time 1 and Time 3 (7 years later). Results The CdLS group were lower in mood than the FXS group overall (p |
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