| Autor: |
Yongjun Guan |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Cell & Bioscience, Vol 9, Iss 1, Pp 1-3 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2045-3701 |
| DOI: |
10.1186/s13578-018-0267-6 |
| Popis: |
Abstract Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex. This breakthrough of Env structure provides insights into HIV-1 fusion mechanism, CCR5 function, co-receptor switch, and, most importantly, the development of co-receptor-targeted therapeutic inhibitor and HIV-1 vaccine. It also shed lights on the immunogenicity of gp120 by revealing the stably exposed conserved gp41-interactive region of gp120 in the complex. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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