Combining host immune response biomarkers and clinical scores for early prediction of sepsis in infection patients
| Autor: | Xiaoming Zhou, Chen Liu, Zhe Xu, Jiaze Song, Haijuan Jin, Hao Wu, Qianhui Cheng, Wenqian Deng, Dongyuan He, Jingwen Yang, Jiaying Lin, Liang Wang, Zhiyi Wang, Chan Chen, Jie Weng |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Annals of Medicine, Vol 56, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 07853890 1365-2060 0785-3890 |
| DOI: | 10.1080/07853890.2024.2396569 |
| Popis: | Background The performance of host immune responses biomarkers and clinical scores was compared to identify infection patient populations at risk of progression to sepsis, ICU admission and mortality.Methods Immune response biomarkers were measured and NEWS, SIRS, and MEWS. Logistic and Cox regression models were employed to evaluate the strength of association.Results IL-10 and NEWS had the strongest association with sepsis development, whereas IL-6 and CRP had the strongest association with ICU admission and in-hospital mortality. IL-6 [HR (95%CI) = 2.68 (1.61–4.46)] was associated with 28-day mortality. Patient subgroups with high IL-10 (≥ 5.03 pg/ml) and high NEWS (> 5 points) values had significantly higher rates of sepsis development (88.3% vs 61.1%; p |
| Databáze: | Directory of Open Access Journals |
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