HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

Autor: Yuan Lin, Zhe-Ping Fang, Hong-Juan Liu, Li-Jing Wang, Zhiqiang Cheng, Na Tang, Tingting Li, Tengfei Liu, Hai-Xiong Han, Guangwen Cao, Li Liang, Yan-Qing Ding, Wei-Jie Zhou
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01341-6
Popis: Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.
Databáze: Directory of Open Access Journals