| Autor: |
Natalia Kozińska, Katarzyna Tokarska, Michał Chudy, Kamil Wojciechowski |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Biophysica, Vol 1, Iss 2, Pp 126-136 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4125 |
| DOI: |
10.3390/biophysica1020010 |
| Popis: |
The purpose of the study was to compare cytotoxicity of two Quillaja saponaria bark saponin (QBS) mixtures against two lung cell lines: normal MRC-5 fibroblast cell line and tumor A-549 epithelial cells of lungs’ alveoli. The study, performed both at a macro-scale and in a dedicated microfluidic device, showed that QBS was more toxic to the cell line more abundant in cholesterol (MRC-5). The QBS mixture with higher saponin fraction was found to be more cytotoxic towards both cell lines. The results may help to better understand the cytotoxicity of saponin-rich herbal medicines towards normal and tumor cells depending on their cholesterol content. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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