IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis

Autor: Natalia A. Lapkina, Andrey A. Baranov, Olga P. Rechkina, Natalia E. Abaytova, Svetlana S. Zolotavkina, Alexander S. Artyuhov, Evgeny L. Nasonov
Jazyk: ruština
Rok vydání: 2024
Předmět:
Zdroj: Научно-практическая ревматология, Vol 62, Iss 4 (2024)
Druh dokumentu: article
ISSN: 1995-4484
1995-4492
DOI: 10.47360/1995-4484-2024-402-407
Popis: The aim of the study was to determine the clinical and diagnostic value of interleukin (IL) 17A, IL-17F and IL-23 in rheumatoid arthritis (RA) patients in the advanced stage of the disease.Materials and methods. We examined 154 patients with a reliable diagnosis of RA according to ACR/EULAR (American College of Rheumatology/European Alliance of Associations for Rheumatology) criteria (2010), predominantly (73.4%) female, middle-aged (56.0 (50.0; 64.0) years), disease duration of 9.4 (3.0; 13.0) years, radiologic stages II (34.4%) and III (37.0%), and moderate to high activity (DAS28-ESR – 5.40 (4.65; 6.00). 83.8% of patients were seropositive for IgM rheumatoid factor (IgM RF) and 68.8% had antibodies to cyclic citrullinated peptide (ACCP). 144 (93.5%) patients were taking DMARDs (methotrexate, leflunamide, sulfasalazine) as well as nonsteroidal antiinflammatory drugs (NSAIDs) and glucocorticoids (GCs) up to 10 mg/day in terms of prednisolone.The serum levels of IL-17A, IL-17F and IL-23 were investigated using multiplex xMAR technology. The upper limit of norm (M+3σ) in 20 sera of healthy donors was 1.78 pg/mL for IL-17A, 9.5 pg/mL for IL-17F and 91.55 pg/mL for IL-23.Results. IL-17A (1.16 (0.50; 2.39) pg/mL) and IL-17F (5.02 (1.00; 138.80) pg/mL) concentrations in RA patients were not significantly different from controls (0.78 (0.00; 1.65) and 4.02 (1.46; 7.31) pg/mL; p>0.05). In contrast, IL-23 levels were significantly higher in patients than in donors (21.36 (2.50; 4626.22) and 14.63 (0.00; 91.55) pg/mL; p
Databáze: Directory of Open Access Journals
Externí odkaz: