| Autor: |
Zhu Jiang, Giulia Sorrentino, Suat Simsek, Joris J.T.H. Roelofs, Hans W.M. Niessen, Paul A.J. Krijnen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100275- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2772-9761 |
| DOI: |
10.1016/j.jmccpl.2024.100275 |
| Popis: |
Background and objectives: Structural and functional changes in the intramyocardial microcirculation increase the risk of myocardial infarction (MI). This study investigated intramyocardial perivascular fibrosis and pro-fibrotic cellular transitions in deceased acute and subacute MI patients to explore their involvement in the pathogenesis of MI. Methods: Left ventricular tissue (LV) was obtained from the infarction area of autopsied patients with acute-phase MI (3–6 h; n = 24), subacute-phase MI (5–14 days; n = 12), and noninfarcted controls (n = 14). Perivascular fibrosis and fibroblast activation protein (FAP) expression were quantified using (immuno)histochemistry. Fibroblast-like transitioning of vascular smooth muscle cells (VSMC) and endothelial cells (EC) was quantified using immunofluorescent microscopy. Results: Perivascular fibrosis was elevated in acute-phase (77.69 %) and subacute-phase (72.19 %: border zone 95.18 %: infarct core) MI patients (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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