Mild NIR controlled NO-Releasing adenine-based composite hydrogel with excellent Antimicrobial, wound adaptiveness and angiogenic capabilities for rapid bacterial-infected wounds healing

Autor: Changyuan He, Ye Wang, Chong Chen, Liubo Yuan, Wentao Dong, Xuekun Yang, Ye Wu, Jialin Liu, Qingquan Kong, Jin He, Bin Yan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Materials & Design, Vol 238, Iss , Pp 112719- (2024)
Druh dokumentu: article
ISSN: 0264-1275
DOI: 10.1016/j.matdes.2024.112719
Popis: Development of wound dressings with antimicrobial activity and promotion of sustained wound healing to reduce the use of antibiotics in infected wounds is important. In this study, we developed a thermosensitive ABA triblock copolymer poly {(N-isopropyl acrylamide)–co-[(6-((3-(6-amino-purin-9-yl)propanoyl)oxy)hexyl acrylates)]-b-PEO-b-Poly (N-isopropyl acrylamide)–co-{[(6-((3-(6-amino-purin-9-yl)propanoyl)oxy)hexyl acrylates)]} as matrix and participating nitric oxide (NO) donor (N,N'-dis-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine, BNN6) loaded SiO2@PDA nanoparticles composed of hydrogel dressings (Gel-APB) for efficient antimicrobial and sustainable treatment of wounds. Thanks to the presence of poly (N-isopropyl acrylamide) (PNIPAM) and unique ABA triblock structure, the NAONA copolymer would self-assemble into temperature-sensitive injectable hydrogel with excellent dermal adaptation to dynamic wounds. Meanwhile, the biobase adenine endowed the hydrogel dressing with self-healing ability. Under 808 nm wavelength irradiation, the hydrogel was able to elevate to a mild temperature (∼48 °C) and release NO on demand, which efficiently kills E. coli and S. aureus, realizing highly efficient and mild photothermal antimicrobial therapy (PTAT). In addition, full-thickness skin wound modeling demonstrated that Gel-APB hydrogel dressing accelerated tissue regeneration, angiogenesis, and collagen deposition in S. aureus infected wounds in vivo, achieving rapid wound healing. Thus, Gel-APB is a multifunctional hydrogel dressing with excellent antimicrobial activity and has considerable potential for application in infected skin wound healing.
Databáze: Directory of Open Access Journals
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