| Autor: |
Yvonne C. F. Su, Michael A. Zeller, Tey Putita Ou, Jordan Ma, Leakhena Pum, Rong Zhang, Sophannadeth Rath, Vireak Heang, Sonita Kol, Reaksa Lim, Kim Lay Chea, Limmey Khun, Leangyi Heng, Sidonn Krang, Philomena Raftery, Michael H. Kinzer, Vanra Ieng, Vannda Kab, Sarika Patel, Borann Sar, Viseth Srey Horm, Sokhoun Yann, Heidi Auerswald, Jurre Y. Siegers, Cecile Troupin, Narjis Boukli, Koen Vandelannoote, Foong Ying Wong, Giselle G. K. Ng, Malen Chan, Sopheak Sorn, Yi Sengdoeurn, Seng Heng, Chau Darapheak, Chin Savuth, Asheena Khalakdina, Sowath Ly, Laurence Baril, Andre Spiegel, Veasna Duong, Sovann Ly, Gavin J. D. Smith, Erik A. Karlsson |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2730-664X |
| DOI: |
10.1038/s43856-024-00685-7 |
| Popis: |
Abstract Background Tracking the emergence, introduction and spread of SARS-CoV-2 variants of concern are essential for informing public health strategies. In 2021, Cambodia faced two major epidemic waves of SARS-CoV-2 triggered by the successive rise of the Alpha and Delta variants. Methods Phylodynamic analysis of 1,163 complete SARS-CoV-2 genomes from Cambodia, along with global sequences, were conducted between February and September 2021 to infer viral introductions, molecular epidemiology and population dynamics. The relationship between epidemic trends and control strategies were evaluated. Bayesian phylogeographic reconstruction was employed to estimate and contrast the spatiotemporal dynamics of the Alpha and Delta variants over time. Results Here we reveal that the Alpha variant displays rapid lineage diversification, accompanied by the acquisition of a spike E484K mutation that coincides with the national implementation of mass COVID-19 vaccination. Despite nationwide control strategies and increased vaccination coverage, the Alpha variant was quickly displaced by Delta variants that exhibits a higher effective reproductive number. Phylogeographic inference indicates that the Alpha variant was introduced through south-central region of Cambodia, with strong diffusion rates from the capital of Phnom Penh to other provinces, while the Delta variant likely entered the country via the northern border provinces. Conclusions Continual genomic surveillance and sequencing efforts, in combination with public health strategies, play a vital role in effectively tracking and responding to the emergence, evolution and dissemination of future emerging variants. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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