Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide

Autor:	Takayuki Tonoi, Takehiko Inohana, Teruyuki Sato, Yuuki Noda, Miyuki Ikeda, Miku Akutsu, Takatsugu Murata, Yutaro Maekawa, Anna Tanaka, Rio Seki, Misako Ohkusu, Katsuhiko Kamei, Naruhiko Ishiwada, Isamu Shiina
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	eushearilide demethyl congener total synthesis lactonization MNBA antimicrobial activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 24, Iss 19, p 3437 (2019)
Druh dokumentu:	article
ISSN:	1420-3049 24193437
DOI:	10.3390/molecules24193437
Popis:	A novel stereoisomer of eushearilide, 23-demethyleushearilide, was synthesized, and the structure−activity relationships of this compound along with known eushearilide stereoisomers were investigated in order to design novel lead compounds for the treatment of fungal infections. It was discovered that all of these congeners, together with the natural product, exhibited a wide range of antimicrobial activity against not only fungi but also against bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
Databáze:	Directory of Open Access Journals
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