| Autor: |
CHEN Siyu, DENG Xiaojuan, ZHANG Yuwei, GOU Yang, ZHANG Xi, PENG Xiangui, WANG Ping |
| Jazyk: |
čínština |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Di-san junyi daxue xuebao, Vol 43, Iss 19, Pp 1909-1912 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1000-5404 |
| DOI: |
10.16016/j.1000-5404.202103215 |
| Popis: |
Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL fusion protein admitted in our department were collected and analyzed. The related literature was reviewed. Results Both cases presented ALL phenotype. FISH test showed BCR-ABL positive, and RQ-PCR (p190, p210, p230) negative. Finally, the rare BCR-ABL fusion gene test was added and the 2 patients were diagnosed as rare e1a3 BCR-ABL positive ALL. One patient received TKI treatment and had achieved complete remission for more than 4 months. Another patient did not receive TKI and died in longer than 1 month after diagnosis. Conclusion Multi-technique joint detection for fusion gene is helpful for the detection and diagnosis of ALL with e1a3 BCR-ABL fusion protein, and TKI therapy is helpful to improve the prognosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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