ASSESSMENT OF RISK FOR CANCER OF THE ENDOMETRIUM IN PATIENTS WITH ITS HYPERPLASTIC PROCESSES AND UTERINE MYOMA IN DIFFERENT AGE GROUPS
| Autor: | N. V. Bochkareva, L. A. Kolomiyets, I. V. Kondakova, A. B. Muntyan, S. L. Stukanov |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Опухоли женской репродуктивной системы, Vol 0, Iss 1-2, Pp 102-107 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1994-4098 1999-8627 |
| DOI: | 10.17650/1994-4098-2009-0-1-2-102-107 |
| Popis: | Based on clinical data, case histories, ultrasound studies, hormonal status, steroid hormone receptor levels, and estrogen metabolic enzyme activities, which are of the greatest informative value, the authors have determined a regression function for assessing a risk for endometrial cancer (EC) in patients with endometrial hyperplastic processes and calculating an individual risk. The application of this model could make an objective assessment of EC progress in these patients and use a treatment option on an individual basis. In patients with endometrial hyperplasia, the sensitivity of the EC risk prediction model was 87.5%; its specificity was 90%; these were 80 and 85.7 in the perimenopause and 92 and 83% in the postmenopause, respectively. For patients with endometrial hyperplasia con- current with uterine myoma, these indices were 87 and 85%, respectively.The mathematical model makes it possible to objectively assess the risk of EC in patient with endometrial hyperplasia in different age groups, to make up increased cancer risk groups, and to plan an individual treatment option, by taking into account both the tradi- tional indicators and the specific features of estrogen reception and metabolism. |
| Databáze: | Directory of Open Access Journals |
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