Low Back Pain, Disability, and Quality of Life One Year following Intradiscal Injection of Autologous Bone Marrow Aspirate Concentrate

Autor: Colin M. Haines, Fenil R. Bhatt, Lindsay D. Orosz, Tarek Yamout, Samuel Namian, Niteesh Bharara, Anthony Bucci, Thomas C. Schuler, Ehsan Jazini, Christopher R. Good
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Stem Cells International, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 1687-9678
DOI: 10.1155/2022/9617511
Popis: Introduction. Degenerative disc disease is a common cause of chronic low back pain. Surgical intervention is an invasive treatment associated with high costs. There is growing interest in regenerative medicine as a less invasive but direct disc treatment for chronic discogenic low back pain. Objective. To evaluate clinical improvement of primary discogenic low back pain with intradiscal injection of autologous bone marrow aspirate concentrate (BMAC). Study Design. Prospective cohort study. Setting. Single, multiphysician center. Patients. 32 adult patients undergoing intradiscal injection of autologous BMAC for the treatment of primary discogenic low back pain. Interventions. Intradiscal injection of autologous BMAC. Main Outcome Measures. Primary outcome measure is visual analog back pain scale (VAS back pain). Secondary outcome measures include ODI, VAS leg pain, and EQ-5D-5L scores. Outcomes were compared from baseline to 1 year. Results. Thirty-two patients (56.3% male) with a mean age of 45.9 years were enrolled, giving 92 treated levels. Mean VAS back and leg pain scores improved from 5.4 to 3.0 (p
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