Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity
| Autor: | E. V. Vorfolomeeva, S. A. Kedik, A. V. Panov, D. V. Vasilyeva |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Тонкие химические технологии, Vol 10, Iss 5, Pp 33-38 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2410-6593 2686-7575 |
| Popis: | In this work partially and completely N-oxidized N-vinylpyrrolidone-2-methyl-5-vinylpyridine copolymers were synthesized. The influence of рН on the reaction course was studied. For obtaining the copolymer N-oxidized by 100% it is necessary to carry out the reaction in an acetate buffer solution. If obtaining the partially N-oxidized copolymer, a citrate buffer solution should be used, which allows carrying out the reaction at a smaller speed and as a result enables to stop the reaction in the necessary range. The dependence of biological activity on the extent of N-oxidation was studied. An immunostimulating effect of N-vinylpyrrolidone-2-methyl-5-vinylpyridine N-oxide copolymers with various extent of N-oxidation was revealed in vivo with an anthrax vaccine. |
| Databáze: | Directory of Open Access Journals |
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