| Autor: |
Patrick T. Magahis, Nicole Cornet, Laura Tang, Kanika Arora, Neha Hingorani, Stephanie King, Arnold J. Markowitz, Mark Schattner, Shoji Shimada, Steven B. Maron, Santosha Vardhana, Melissa Lumish, Andrea Cercek, Yelena Y. Janjigian, Daniel Coit, Robin B. Mendelsohn, Michael F. Berger, Vivian E. Strong, Zsofia K. Stadler, Monika Laszkowska |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Cancer Medicine, Vol 13, Iss 23, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.70451 |
| Popis: |
ABSTRACT Background There has been a paradoxical rise in young‐onset gastric cancer (YOGC), defined as gastric cancer (GC) diagnosed before age 50. Precursor lesions may contribute to pathogenesis, though their role in progression to different histologic subtypes is unclear. The impact of self‐reported race is also poorly characterized and may be unreliable as a proxy for genetic differences. We aimed to compare differences in histology and genetic ancestry between YOGC and average‐onset gastric cancer (AOGC). Methods This retrospective cohort included all patients with GC at Memorial Sloan Kettering (MSK) from January 2013 to March 2021. Data on demographics, tumor characteristics, and precursor lesions were collected. Genetic ancestry was inferred from MSK‐Integrated Mutation Profiling of Actionable Cancer Targets panel. Results Of 1685 individuals with GC, 290 had YOGC. Compared to AOGC, individuals with YOGC tended to be female, Hispanic, foreign‐born, and feature diffuse‐type histology. YOGC was less likely to have precursor lesions, including intestinal metaplasia (20% vs. 37%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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