| Autor: |
Mariam L. Alam, Ronit Katz, Keith A. Bellovich, Zeenat Y. Bhat, Frank C. Brosius, Ian H. de Boer, Crystal A. Gadegbeku, Debbie S. Gipson, Jennifer J. Hawkins, Jonathan Himmelfarb, Bryan R. Kestenbaum, Matthias Kretzler, Cassianne Robinson-Cohen, Susan P. Steigerwalt, Courtney Tuegel, Nisha Bansal |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Kidney International Reports, Vol 4, Iss 1, Pp 103-111 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2468-0249 |
| DOI: |
10.1016/j.ekir.2018.09.013 |
| Popis: |
Introduction: Cardiac biomarkers soluble ST2 (sST2) and galectin-3 may reflect cardiac inflammation and fibrosis. It is plausible that these mechanisms may also contribute to the progression of kidney disease. We examined associations of sST2 and galectin-3 with kidney function decline in participants with chronic kidney disease (CKD). Methods: This was a pooled analysis of 2 longitudinal cohorts of participants with CKD: the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS). We measured circulating concentrations of sST2 and galectin-3 at baseline. Our primary outcome was progression to estimated glomerular filtration rate (eGFR) |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
