Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp.

Autor: Qi Wang, Xuli Tang, Hui Liu, Xiangchao Luo, Ping Jyun Sung, Pinglin Li, Guoqiang Li
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Marine Drugs, Vol 18, Iss 3, p 171 (2020)
Druh dokumentu: article
ISSN: 1660-3397
DOI: 10.3390/md18030171
Popis: The chemical examination of the marine soft coral Lemnalia sp., collected at the Xisha islands in the South China Sea, resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely clavukoellians G−J (1−4), and one new aristolane sesquiterpene, namely clavukoellian K (5), together with five known compounds, 6−10. The structure elucidation of the isolated natural products was based on various spectroscopic techniques including HRESIMS and NMR, while their absolute configurations were resolved on the basis of comparisons of the ECD spectra with the calculated ECD data. The isolated new compounds 1−5 were evaluated for their anti- and pro- angiogenesis activities in a transgenic fluorescent zebrafish (Tg(vegfr2:GFP)) model. Quantitative analysis revealed that compound 5 displayed pro-angiogenesis activity in a PTK787-induced vascular injury zebrafish model at 2.5 μM. Data showed that compound 5 significantly promoted the angiogenesis in a dose-dependent manner.
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