The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding

Autor: Sijia Hao, Hongbin Yang, Xiaomeng Wang, Yang He, Haifeng Xu, Xiaotong Wu, Libiao Pan, Yijun Liu, Huifang Lou, Han Xu, Huan Ma, Wang Xi, Yudong Zhou, Shumin Duan, Hao Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Cell Reports, Vol 28, Iss 3, Pp 616-624.e5 (2019)
Druh dokumentu: article
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.06.051
Popis: Summary: Overeating is a serious issue in modern society, causing many health problems, including obesity. Although the hypothalamus has been previously identified as the key brain structure that regulates body weight homeostasis, the downstream pathways and non-canonical neural circuitry involved in feeding behavior remain largely uncharacterized. Here, we discover that suppressing the activity of GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection GABAergic inputs from either the bed nucleus of the stria terminalis (BNST) or the lateral hypothalamus (LH), is sufficient to promptly induce feeding behavior in well-fed mice. In contrast, optogenetic activation of these cells interrupts food intake in starved mice. Long-term chemogenetic manipulation of vlPAG GABAergic cell activity elicits a corresponding change in mouse body weight. Our studies reveal distinct midbrain GABAergic pathways and highlight an important role of GABAergic cells in the anterior vlPAG in feeding behavior. : Hao et al. uncovered an important role of the GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG) and two distinct midbrain GABAergic pathways (the lateral hypothalamus-vlPAG and BNST-vlPAG) in regulation of feeding behavior. Keywords: feeding, vlPAG, GABAergic pathway, lateral hypothalamus, mice
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