Inhibition of hepatocellular carcinoma cells through ferroptosis therapy using Fe3O4/Ag nanocomposites

Autor: Hongfeng Lin, Jianhong Chen, Zhongyan Zhang, Yuxu Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Materials Research Express, Vol 11, Iss 6, p 065403 (2024)
Druh dokumentu: article
ISSN: 2053-1591
DOI: 10.1088/2053-1591/ad4cbd
Popis: In the current study, Fe _3 O _4 /Ag nanohybrids demonstrating high efficiency in liver cancer ferroptosis therapy and MR imaging were synthesized using a facile one-pot approach. Subsequently, their morphology, chemical composition, structure, Fenton reaction activity, and magnetic resonance (MR) contrast effect were systemically assessed. Importantly, the in vitro studies demonstrated that the Fe _3 O _4 /Ag nanohybrids had a high therapeutic efficiency in treating liver cancer cells and performed exceptionally well during T _2 -weight MR imaging. Correspondingly, these Fe _3 O _4 /Ag nanohybrids demonstrate significant potential for use in the field of biomedicine.
Databáze: Directory of Open Access Journals