Proton-pump inhibitor vs. H2-receptor blocker use and overall risk of CKD progression

Autor: Liza Cholin, Tarek Ashour, Ali Mehdi, Jonathan J. Taliercio, Remy Daou, Susana Arrigain, Jesse D. Schold, George Thomas, Joseph Nally, Nazih L. Nakhoul, Georges N. Nakhoul
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Nephrology, Vol 22, Iss 1, Pp 1-8 (2021)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-021-02449-0
Popis: Abstract Background The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Specifically, there is a lack of data evaluating renal outcomes in established CKD patients. The aim of our study is to determine the risk of progression to end-stage kidney disease (ESKD) or death amongst CKD patients on PPI, histamine-2 receptor blocker (H2B), or no anti-acid therapy. Methods Using our CKD registry, we evaluated the relationship between PPI and H2B use and outcomes amongst patients with CKD (eGFR
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