Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

Autor: Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Royal Society Open Science, Vol 5, Iss 2 (2018)
Druh dokumentu: article
ISSN: 2054-5703
DOI: 10.1098/rsos.171249
Popis: Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.
Databáze: Directory of Open Access Journals