| Autor: |
Frédéric Marin, Elke Warmerdam, Zoé Marin, Khalil Ben Mansour, Walter Maetzler, Clint Hansen |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Sensors, Vol 22, Iss 21, p 8340 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1424-8220 |
| DOI: |
10.3390/s22218340 |
| Popis: |
Monitoring disease progression in Parkinson’s disease is challenging. Postural transfers by sit-to-stand motions are adapted to trace the motor performance of subjects. Wearable sensors such as inertial measurement units allow for monitoring motion performance. We propose quantifying the sit-to-stand performance based on two scores compiling kinematics, dynamics, and energy-related variables. Three groups participated in this research: asymptomatic young participants (n = 33), senior asymptomatic participants (n = 17), and Parkinson’s patients (n = 20). An unsupervised classification was performed of the two scores to differentiate the three populations. We found a sensitivity of 0.4 and a specificity of 0.96 to distinguish Parkinson’s patients from asymptomatic subjects. In addition, seven Parkinson’s patients performed the sit-to-stand task “ON” and “OFF” medication, and we noted the scores improved with the patients’ medication states (MDS-UPDRS III scores). Our investigation revealed that Parkinson’s patients demonstrate a wide spectrum of mobility variations, and while one inertial measurement unit can quantify the sit-to-stand performance, differentiating between PD patients and healthy adults and distinguishing between “ON” and “OFF” periods in PD patients is still challenging. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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