| Autor: |
Yanjun Liang, Shuang Liang, Dayang Xie, Xinru Guo, Chen Yang, Tuo Xiao, Kaiting Zhuang, Yongxing Xu, Yong Wang, Bin Wang, Zhou Zhang, Xiangmei Chen, Yizhi Chen, Guangyan Cai |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2024.1348854 |
| Popis: |
BackgroundExisting studies investigating the impact of serum calcium (Ca), phosphate (P), 25 hydroxyvitamin D (25[OH]D), and parathyroid hormone (PTH) levels on kidney function have produced inconsistent results. Further research is needed to establish the direct causal relationship between these factors and kidney function.MethodsThe study used genome-wide association study datasets for exposure and outcome, mainly derived from the UK Biobank and CKDGen Consortium, with sample sizes ranging from 3,310 to 480,699 individuals of European ancestry. Heritability and genetic correlations among these phenotypes were assessed using linkage disequilibrium score regression (LDSC) and phenotypes with a heritability z-score |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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