Association of Low‐Density Lipoprotein Cholesterol Levels During Statin Treatment With Cardiovascular and Renal Outcomes in Patients With Moderate Chronic Kidney Disease

Autor: Chieh‐Li Yen, Pei‐Chun Fan, Cheng‐Chia Lee, Jia‐Jin Chen, George Kuo, Yi‐Ran Tu, Pao‐Hsien Chu, Hsiang‐Hao Hsu, Ya‐Chung Tian, Chih‐Hsiang Chang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.122.027516
Popis: Background The benefit of low‐density lipoprotein cholesterol (LDL‐C) levels in chronic kidney disease populations remains unclear. This study evaluated the cardiovascular and renal outcomes in patients with stage 3 chronic kidney disease with different LDL‐C levels during statin treatment. Methods and Results There were 8500 patients newly diagnosed as having stage 3 chronic kidney disease under statin treatment who were identified from the Chang Gung Research Database and divided into 3 groups according to their first LDL‐C level after the index date: 100 mg/dL. Inverse probability of treatment weighting was performed to balance baseline characteristics. Compared with the LDL‐C ≥100 mg/dL group, the 70≤LDL‐C100 mg/dL. Moreover, the 70≤LDL‐C
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