Effects of eicosapentaenoic acid and docosahexaenoic acid on C2C12 cell adipogenesis and inhibition of myotube formation

Autor:	Saeed Ghnaimawi, Sarah Shelby, Jamie Baum, Yan Huang
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	n-3 pufas adipogenesis myoblasts epa dha Medicine (General) R5-920 Biology (General) QH301-705.5
Zdroj:	Animal Cells and Systems, Vol 23, Iss 5, Pp 355-364 (2019)
Druh dokumentu:	article
ISSN:	1976-8354 2151-2485 19768354
DOI:	10.1080/19768354.2019.1661282
Popis:	Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulate cellular metabolic functions and gene expression. This study investigated the impacts of EPA and DHA on gene expression and morphological changes during adipogenic inducement in C2C12 myoblasts. Cells were cultured and treated with differentiation medium with and without 50 μM EPA and DHA. Cells treated with fatty acids had noticeable lipid droplets, but no formation of myotubes compared to control group cells. The expression levels of key genes relevant to adipogenesis and inflammation were significantly higher (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b5b0d44509b946ee98ff04911cfb262c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.