Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

Autor: Bader Al Alwan, Karmen AbuZineh, Shuho Nozue, Aigerim Rakhmatulina, Mansour Aldehaiman, Asma S. Al-Amoodi, Maged F. Serag, Fajr A. Aleisa, Jasmeen S. Merzaban, Satoshi Habuchi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02398-2
Popis: Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.
Databáze: Directory of Open Access Journals
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