A Multimodality Myocardial Perfusion Phantom: Initial Quantitative Imaging Results

Autor: Marije E. Kamphuis, Henny Kuipers, H. Remco Liefers, Jan van Es, Frank F. J. Simonis, Marcel J. W. Greuter, Cornelis H. Slump, Riemer H. J. A. Slart
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Bioengineering, Vol 9, Iss 9, p 436 (2022)
Druh dokumentu: article
ISSN: 2306-5354
DOI: 10.3390/bioengineering9090436
Popis: This proof-of-concept study explores the multimodal application of a dedicated cardiac flow phantom for ground truth contrast measurements in dynamic myocardial perfusion imaging with CT, PET/CT, and MRI. A 3D-printed cardiac flow phantom and flow circuit mimics the shape of the left ventricular cavity (LVC) and three myocardial regions. The regions are filled with tissue-mimicking materials and the flow circuit regulates and measures contrast flow through LVC and myocardial regions. Normal tissue perfusion and perfusion deficits were simulated. Phantom measurements in PET/CT, CT, and MRI were evaluated with clinically used hardware and software. The reference arterial input flow was 4.0 L/min and myocardial flow 80 mL/min, corresponding to myocardial blood flow (MBF) of 1.6 mL/g/min. The phantom demonstrated successful completion of all processes involved in quantitative, multimodal myocardial perfusion imaging (MPI) applications. Contrast kinetics in time intensity curves were in line with expectations for a mimicked perfusion deficit (38 s vs. 32 s in normal tissue). Derived MBF in PET/CT and CT led to under- and overestimation of reference flow of 0.9 mL/g/min and 4.5 mL/g/min, respectively. Simulated perfusion deficit (0.8 mL/g/min) in CT resulted in MBF of 2.8 mL/g/min. We successfully performed initial, quantitative perfusion measurements with a dedicated phantom setup utilizing clinical hardware and software. These results showcase the multimodal phantom’s potential.
Databáze: Directory of Open Access Journals
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