Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?

Autor:	Tim I. M. Korevaar
Jazyk:	English<br />Korean
Rok vydání:	2022
Předmět:	pregnancy thyroid gland thyroperoxidase antibodies Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Endocrinology and Metabolism, Vol 37, Iss 3, Pp 387-391 (2022)
Druh dokumentu:	article
ISSN:	2093-596X 2093-5978
DOI:	10.3803/EnM.2022.301
Popis:	Thyroperoxidase antibody (TPOAb) positivity is a well-known risk factor for thyroid dysfunction during pregnancy and is associated with a suboptimal response to thyroidal stimulation by human chorionic gonadotropin. About 75% of TPOAb positive women are euthyroid and there seems to be a higher risk of predominantly miscarriage and preterm birth in this subgroup. Nonetheless, clinical decision making with regards to gestational levothyroxine treatment remains difficult due to a lack of large randomized trials. Future studies assessing dose-dependent associations and additional biomarkers that can distinguish low-risk from high-risk individuals will be key in disentangling the crude clinical data.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b591c72f427841ee9800033ad4b04b71 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF