Alkaloids from Hippeastrum papilio
| Autor: | Jaume Bastida, Jean Paulo de Andrade, José Angelo S. Zuanazzi, Carles Codina, Francesc Viladomat, Strahil Berkov |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Molecules, Vol 16, Iss 8, Pp 7097-7104 (2011) |
| Druh dokumentu: | article |
| ISSN: | 16087097 1420-3049 |
| DOI: | 10.3390/molecules16087097 |
| Popis: | Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine. |
| Databáze: | Directory of Open Access Journals |
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