LH supplementation of ovarian stimulation protocols influences follicular fluid steroid composition contributing to the improvement of ovarian response in poor responder women

Autor:	S. Marchiani, L. Tamburrino, F. Benini, M. Pallecchi, C. Bignozzi, A. Conforti, C. Alviggi, L. Vignozzi, G. Danza, S. Pellegrini, E. Baldi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-020-69325-z
Popis:	Abstract In this prospective study, we evaluated the steroid levels in 111 follicular fluids (FF) collected from 13 women stimulated with FSH monotherapy and 205 FF collected from 28 women stimulated with FSH + LH because of a previous history of hypo-responsiveness to FSH. Steroid levels were measured by HPLC/MS–MS and related to ovarian stimulation protocol, oocyte maturity, fertilization and quality of blastocysts, after individually tracking the fate of all retrieved oocytes. 17-Hydroxy-Progesterone, Androstenedione, Estradiol and Estrone were significantly higher in the FSH + LH protocol. Progesterone, 17-Hydroxy-Progesterone and Estradiol were more expressed in FF yielding a mature oocyte (p
Databáze:	Directory of Open Access Journals
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