| Autor: |
Juliette Rochefort, Ioannis Karagiannidis, Claude Baillou, Lisa Belin, Maude Guillot-Delost, Rodney Macedo, Aline Le Moignic, Véronique Mateo, Patrick Soussan, Isabelle Brocheriou, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean, Chloé Bertolus, Francois Michel Lemoine, Géraldine Lescaille |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2022.1068979 |
| Popis: |
IntroductionOral Squamous Cell Carcinomas (OSCC) are mostly related to tobacco consumption eventually associated to alcohol (Smoker/Drinker patients: SD), but 25-30% of the patients have no identified risk factors (Non-Smoker/Non-Drinker patients: NSND). We hypothesized that these patients have distinguishable immune profiles that could be useful for prognosis.Materials and MethodsCells present in immune tumor microenvironment (TME) and blood from 87 OSCC HPV-negative patients were analyzed using a multiparameter flow cytometry assay, in a prospective case-control study. Cytokine levels in tumor supernatants and blood were determined by a cytometric bead array (CBA) assay.ResultsNormal gingiva and blood from healthy donors (HD) were used as controls. A significant increase of granulocytes (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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