Interactive effects of intrinsic capacity and obesity on the KDIGO chronic kidney disease risk classification in older patients with type 2 diabetes mellitus

Autor: Wei-Hua Tang, Teng-Hung Yu, Hui-Lan Lee, Yau-Jiunn Lee
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-022-00975-x
Popis: Abstract Background Intrinsic capacity (IC) is a novel concept focusing on normal and healthy aging. The effect of IC on the risk of chronic kidney disease (CKD) according to KDIGO category in older type 2 diabetes mellitus (T2DM) patients has rarely been studied. We investigated whether a decline in IC is associated with the risk of CKD according to KDIGO 2012 categories. Methods This is a cross-sectional study. The exposure variables (IC score and body mass index) and outcome variable (KDIGO categories of the risk of CKD) were collected at the same timepoint. A total of 2482 older subjects with T2DM managed through a disease care program were enrolled. The five domains of IC, namely locomotion, cognition, vitality, sensory, and psychological capacity were assessed. Based on these domains, the IC composite score was calculated. CKD risk was classified according to the KDIGO 2012 CKD definition. Univariate and multivariate analyses were used to assess the association between IC score and KDIGO categories of risk of CKD. Results The KDIGO CKD risk category increased in parallel with IC score (p for trend
Databáze: Directory of Open Access Journals
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