| Autor: |
Fatemeh Ahmadi, Mohsen Ahmadi-Fakhr, Ali Dehshahri, Elahehnaz Parhizkar |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Trends in Pharmaceutical Sciences, Vol 9, Iss 3, Pp 213-220 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2423-5652 |
| DOI: |
10.30476/tips.2023.99454.1204 |
| Popis: |
Taxanes are a class of potent anticancer agents used in different cancers. Their low water solubility is the major challenge in formulation development that leads to the use of surfactants and organic solvents which causes severe hypersensitivity reactions. In this study, paclitaxel (PTX) was conjugated to a water-soluble and biocompatible polymer, dextran, to enhance solubility. Levothyroxine was also conjugated to dextran to provide targeted delivery. The cytotoxicity was studied on HepG2 and A375 cell lines before and after treating cell lines with levothyroxine. Results showed approximately 1250-fold water solubility enhancement by dextran conjugation. Drug conjugates presented higher cytotoxicity on A375 cell lines than its free drug counterparts at 10 and 50 nM concentrations after 24 hours. Pre-treatment with levothyroxine decreased the cytotoxicity on A375 as an integrin receptor rich cell line but did not show any significant effect on HepG2 cells which is low in expressing integrin receptor. In conclusion, preparation of levothyroxine targeted dextran conjugate might be an effective strategy for PTX delivery to different cell lines. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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