Autor: |
Lucia Krivosikova, Tereza Kuracinova, Peter Martanovic, Michaela Hyblova, Jozef Kaluzay, Alexandra Uhrinova, Pavol Janega, Pavel Babal |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Viruses, Vol 15, Iss 9, p 1810 (2023) |
Druh dokumentu: |
article |
ISSN: |
1999-4915 |
DOI: |
10.3390/v15091810 |
Popis: |
After the acute phase of COVID-19, some patients develop long COVID. This term is used for a variety of conditions with a complex, yet not fully elucidated etiology, likely including the prolonged persistence of the virus in the organism and progression to lung fibrosis. We present a unique autopsy case of a patient with severe COVID-19 with prolonged viral persistence who developed interstitial lung fibrosis complicated by a fatal combination of cytomegalovirus and Aspergillus infection. SARS-CoV-2 virus was detected at autopsy in the lungs more than two months after the acute infection, although tests from the nasopharynx were negative. Immune dysregulation after COVID-19 and the administration of corticoid therapy created favorable conditions for the cytomegalovirus and Aspergillus infection that were uncovered at autopsy. These pathogens may represent a risk for opportunistic infections, complicating not only the acute coronavirus infection but also long COVID, as was documented in the presented case. |
Databáze: |
Directory of Open Access Journals |
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