Autor: |
Enders K O Ng, Candy P H Leung, Vivian Y Shin, Chris L P Wong, Edmond S K Ma, Hong Chuan Jin, Kent-Man Chu, Ava Kwong |
Jazyk: |
angličtina |
Rok vydání: |
2011 |
Předmět: |
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Zdroj: |
PLoS ONE, Vol 6, Iss 7, p e22233 (2011) |
Druh dokumentu: |
article |
ISSN: |
1932-6203 |
DOI: |
10.1371/journal.pone.0022233 |
Popis: |
BACKGROUND: Previously, we have examined the methylation status of SLC19A3 (solute carrier family 19, member 3) promoter and found that SLC19A3 was epigenetically down-regulated in gastric cancer. Here, we aim to develop a new biomarker for cancer diagnosis using methylated SLC19A3 DNA in plasma. METHODOLOGY/PRINCIPAL FINDINGS: SLC19A3 gene expression was examined by RT-qPCR. Methylation status of SLC19A3 promoter was evaluated by methylation-specific qPCR. SLC19A3 expression was significantly down-regulated in 80% (12/15) of breast tumors (P |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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