Comprehensive Profiling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson’s Disease

Autor: Amit Sharma, Jens Müller, Karin Schuetze, Verena Rolfes, Rosi Bissinger, Nathalia Rosero, Ashar Ahmad, Bernardo S Franklin, Berndt Zur, Holger Fröhlich, Florian Lang, Johannes Oldenburg, Bernd Pötzsch, Ullrich Wüllner
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biology, Vol 10, Iss 8, p 716 (2021)
Druh dokumentu: article
ISSN: 10080716
2079-7737
DOI: 10.3390/biology10080716
Popis: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. Accumulating evidence demonstrates that alpha-synuclein (α-Syn), an apparently predominant neuronal protein, is a major contributor to PD pathology. As α-Syn is also highly abundant in blood, particularly in red blood cells (RBCs) and platelets, this in turn raises the question on the function of presumably dysfunctional α-Syn in “peripheral” cells and its putative effect on the other enclosed constituents. Herein, we detected the internal variance in erythrocytes of PD patients by Raman spectroscopy, but no measurable amount of erythrocytic behavioural change (eryptosis) or any haemoglobin variation was noticed. An elevated level of plasmin-antiplasmin complexes (PAP) was observed in the plasma of PD patients, indicating activation of the fibrinolytic system, but platelet activation after thrombin stimulation was not altered. Sex-specific patterns were noticed for blood coagulation factor XIII and factor XII activity in PD patients. Additionally, the alterations in homocysteine levels which have often been observed in PD patients were found to be independent from L-DOPA usage and PAP levels. Furthermore, a selective gene expression analysis identified subsets of genes related to different blood-associated compartments (RBCs, platelets, coagulation-fibrinolysis) also involved in PD-related pathways.
Databáze: Directory of Open Access Journals
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