| Autor: |
Soon-Kyung Hwang, Yun-Jeong Jeong, Hyun-Ji Cho, Yoon-Yub Park, Kwon-Ho Song, Young-Chae Chang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Ginseng Research, Vol 46, Iss 1, Pp 138-146 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1226-8453 |
| DOI: |
10.1016/j.jgr.2021.05.005 |
| Popis: |
Background: Red Ginseng has been used for many years to treat diseases. Ginsenoside Rg3 has documented therapeutic effects, including anticancer and anti-inflammatory activities. However, the anticancer effect of Rg3-enriched red ginseng extract (Rg3-RGE) and its underlying mechanisms have not been fully explored. We investigated whether Rg3-RGE plays an anti-tumor role in lung cancer cells. Methods: To examine the effect of Rg3-RGE on lung cancer cells, we performed cell viability assays, flow cytometry, western blotting analysis, and immunofluorescence to monitor specific markers. Results: Rg3-RGE significantly inhibited cell proliferation and induced mitochondria-dependent apoptosis. Furthermore, Rg3-RGE also increased expression of mitophagy-related proteins such as PINK1 and Parkin. In addition, treatment with Rg3-RGE and mitophagy inhibitors stimulated cell death by inducing mitochondria dysfunction. Conclusions: Rg3-RGE could be used as a therapeutic agent against lung cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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